Lipids Fraction from Caralluma europaea (Guss.): MicroTOF and HPLC Analyses and Exploration of Its Antioxidant, Cytotoxic, Anti-Inflammatory, and Wound Healing Effects

Caralluma europaea is a medicinal plant used in Morocco to cure variety of illnesses. This study was conducted determine the chemical composition, antioxidant, antiproliferative, anti-inflammatory, and wound healing activities C. lipids. The composition analyzed using time-of-flight mass spectrometry high-performance liquid chromatography. antioxidant potential determined 2,2-di-phenyl-1-picryl hydrazyl (DPPH), ferric reducing power (FRAP) tests. antiproliferative effect evaluated by MTT assay against HL60, K562, Huh-7 cancer cells, normal Vero cells. anti-inflammatory carrageenan-induced paw edema. skin burns for 21 days. identified phytochemical compounds were docked their on nicotinamide adenine dinucleotide phosphate oxidase, caspase-3, lipoxygenase, glycogen synthase kinase-3-β, protein casein kinase-1. results showed presence some lipids, such as linoleic acid vitamin D3. DPPH (IC50 = 0.018 mg/mL) FRAP (EC50 0.084 lipids an important effect. For test, inhibition 83.50% recorded after 6 h treatment. Our extract greatest retraction 21st day (98.20%). remarkable antitumoral K562 cell line 37.30 µg/mL), with no cells > 100 µg/mL). Lignoceric most active molecule caspase-3 (−6.453 kcal/mol). findings indicate growing evidence treatment several diseases.